Tuesday, January 26, 2016

Late to the Party

I was just reading this paper called "The early evolution of lipid membranes and the three domains of life" from 2012 in Nature Reviews. It talks about the dominant research areas on the origin of life:

Despite the crucial role of membranes in allowing the genetic and metabolic systems to interact and evolve together, most studies on the origin and early evolution of life have focused on the emergence of either the genetic system or energy and carbon metabolism
 But they go on to say that a focus on membranes as an early key component is changing:
This avenue of research is progressing quickly, to the point that the traditional focus on self-maintenance (metabolism) as a major property of life, together with self-replication (a genetic system), is shifting towards a focus on self-assembly (membranes) in contemporary origin-of-life thinking.
And they give references that I'll have to look up:

  • Mansy, S. S. et al. Template-directed synthesis of a genetic polymer in a model protocell. Nature 454, 122–125 (2008).
  • Segre, D., Ben-Eli, D., Deamer, D. W. & Lancet, D. The lipid world. Orig. Life Evol. Biosph. 31, 119–145 (2001).
  • Mansy, S. S. & Szostak, J. W. Reconstructing the emergence of cellular life through the synthesis of model protocells. Cold Spring Harb. Symp. Quant. Biol. 74, 47–54 (2009).

It looks like I'm late to the party with my idea about focusing on membranes. However, the article doesn't mention autocatalytic sets. I'll have to see if any of the references mention them.

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